| Date | Location | Result | |
| Dec 02, 2021 | Big Rapids, Mich. | Michigan Tech 3, Wayne State 2 (25-16,25-20,18-25,19-25,15-8) | Box score |
| Nov 20, 2021 | Houghton,MI | Ferris State 3, Wayne State 1 (25-21,25-16,23-25,25-21) | Box score |
| Nov 17, 2021 | Detroit, MI | Wayne State 3, Saginaw Valley 0 (25-13,25-16,25-21) | Box score |
| Nov 13, 2021 | Detroit, MI | Michigan Tech 3, Wayne State 0 (25-23,25-17,25-22) | Box score |
| Nov 12, 2021 | Detroit, MI | Northern Mich. 3, Wayne State 2 (21-25,25-21,25-17,13-25,16-14) | Box score |
| Nov 5, 2021 | University City, MI | Wayne State 3, Saginaw Valley 2 (25-18,25-23,21-25,17-25,15-13) | Box score |
| Oct 30, 2021 | Sault Ste. Marie, MI | Wayne State 3, Lake Superior St. 0 (25-14,25-14,25-13) | Box score |
| Oct 29, 2021 | Midland, Mich. | Wayne State 3, Northwood 0 (25-23,25-23,25-23) | Box score |
| Oct 23, 2021 | Detroit, MI | Wayne State 3, Saginaw Valley 0 (25-20,25-20,25-22) | Box score |
| Oct 16, 2021 | Hammond, IN | Wayne State 3, Ohio Dominican 2 (22-25,25-17,18-25,25-17,15-9) | Box score |
| Oct 15, 2021 | Hammond, IN | Wayne State 3, Rockhurst 1 (25-20,25-14,23-25,25-22) | Box score |
| Oct 15, 2021 | Hammond, IN | Ashland 3, Wayne State 1 (17-25,26-24,25-15,25-22) | Box score |
| Oct 10, 2021 | Detroit, MI | Wayne State 3, Grand Valley St. 1 (25-22,17-25,25-23,25-17) | Box score |
| Oct. 9, 2021 | Detroit, MI | Ferris St. 3, Wayne State 0 (25-20,25-19,25-18) | Box score |
| Oct. 8, 2021 | Detroit, MI | Wayne State 3, Davenport 0 (25-15,25-15,25-18) | Box score |
| 10/02/21 | Marquette, MI | Wayne State 3, Northern Mich. 0 (25-21,25-19,25-20) | Box score |
| Oct 01, 2021 | Houghton, MI | Michigan Tech 3, Wayne State 1 (25-12,23-25,26-24,25-23) | Box score |
| Sep 25, 2021 | Hammond, IN | Wayne State 3, Purdue Northwest 0 (25-23,25-18,25-18) | Box score |
| Sep 24, 2021 | Kenosha, WI | Wayne State 3, Wis.-Parkside 1 (23-25,25-21,25-20,25-17) | Box score |
| Sep 18, 2021 | Detroit, MI | Wayne State 3, Northwood 0 (25-15,25-13,25-23) | Box score |
| Sep 17, 2021 | Detroit, MI | Wayne State 3, Lake Superior St. 0 (25-17,25-17,25-20) | Box score |
| Sep 11, 2021 | Evansville, IN | Southern Ind. 3, Wayne State 0 (25-12,25-23,25-14) | Box score |
| Sep 11, 2021 | Evansville, IN | Wayne State 3, Davis & Elkins 1 (25-11,25-22,15-25,25-21) | Box score |
| Sep 10, 2021 | Evansville, IN | Wayne State 3, Alabama Huntsville 1 (26-28,25-21,25-16,26-24) | Box score |
| Sep 10, 2021 | Evansville, IN | Mo.-St. Louis 3, Wayne State 1 (25-17,25-15,22-25,25-15) | Box score |
| Sep 4, 2021 | Detroit, MI | Wayne State 3, Walsh 2 (25-19,28-26,22-25,26-28,15-11) | Box score |
| Sept 4, 2021 | Detroit, MI | Wayne State 3, East Stroudsburg 0 (25-16,25-22,25-17) | Box score |
| Sept 3, 2021 | Detroit, MI | Wayne State 3, West Liberty 0 (25-14,25-17,25-17) | Box score |
| Sept 3, 2021 | Detroit, MI | Wayne State 3, Daemen 0 (25-21,25-13,25-14) | Box score |