| Date | Location | Result | |
| Nov 13, 2021 | Big Rapids, Mich. | Ferris State 35, Wayne State 13 | Box score |
| Nov 06, 2021 | Detroit, Michigan | Grand Valley St. 62, Wayne State 13 | Box score |
| Oct 30, 2021 | Detroit, Michigan | Wayne State 56, Northwood 21 | Box score |
| Oct 23, 2021 | Univ. Center, Mich. | Saginaw Valley 41, Wayne State 25 | Box score |
| Oct 16, 2021 | Caledonia, Michigan | Wayne State 16, Davenport 3 | Box score |
| Oct 09, 2021 | Detroit, Mich. | Michigan Tech 30, Wayne State 27 | Box score |
| Oct 02, 2021 | Marquette, Michigan | Northern Mich. 26, Wayne State 19 | Box score |
| Sep 25, 2021 | Detroit, Michigan | Saginaw Valley 41, Wayne State 21 | Box score |
| Sep 18, 2021 | Rolla, Missouri | Missouri S&T 51, Wayne State 45 | Box score |
| Sep 11, 2021 | Detroit, Michigan | Truman 27, Wayne State 9 | Box score |
| Sep 02, 2021 | Detroit, Michigan | Slippery Rock 24, Wayne State 21 | Box score |