| Date | Location | Result | |
| May 22, 2022 | Detroit, Mich. | Ill.-Springfield 6, Wayne State 3 | Box score |
| May 21, 2022 | Detroit, Mich. | Wayne State 15, Walsh 11 | Box score |
| May 20, 2022 | Detroit, Mich. | Wayne State 10, Ashland 3 | Box score |
| May 19, 2022 | Detroit, Mich. | Walsh 6, Wayne State 3 | Box score |
| May 14, 2022 | Gary, Ind. | Davenport 8, Wayne State 5 | Box score |
| May 14, 2022 | Hammond, Ind. | Purdue Northwest 7, Wayne State 5 | Box score |
| May 13, 2022 | Gary, Ind. | Wayne State 7, Northwood 4 | Box score |
| May 12, 2022 | Gary, Ind. | Wayne State 10, Saginaw Valley 4 | Box score |
| May 8, 2022 | Romeoville, Ill. | Wayne State 6, Lewis 5 | Box score |
| May 7, 2022 | Romeoville, Ill. | Lewis 2, Wayne State 1 | Box score |
| May 7, 2022 | Romeoville, Ill. | Wayne State 14, Lewis 0 | Box score |
| May 5, 2022 | Kenosha, Wis. | Wayne State 11, Parkside 0 | Box score |
| May 1, 2022 | Detroit, Mich. | Purdue Northwest 11, Wayne State 10 | Box score |
| Apr 30, 2022 | Detroit, Mich. | Wayne State 9, Purdue Northwest 2 | Box score |
| Apr 30, 2022 | Detroit, Mich. | Wayne State 9, Purdue Northwest 2 | Box score |
| Apr 29, 2022 | Detroit, Mich. | Wayne State 23, Purdue Northwest 4 | Box score |
| Apr 26, 2022 | Detroit, Mich. | Hillsdale 6, Wayne State 4 | Box score |
| Apr 24, 2022 | Midland, Mich. | Wayne State 21, Northwood 15 | Box score |
| Apr 23, 2022 | Midland, Mich. | Northwood 13, Wayne State 3 | Box score |
| Apr 23, 2022 | Midland, Mich. | Northwood 7, Wayne State 3 | Box score |
| Apr 22, 2022 | Midland, Mich. | Northwood 8, Wayne State 1 | Box score |
| Apr 19, 2022 | Detroit, Mich. | Wayne State 14, Findlay 8 | Box score |
| Apr 19, 2022 | Detroit, Mich. | Wayne State 11, Findlay 0 | Box score |
| Apr 16, 2022 | Detroit, Mich. | Wayne State 8, Grand Valley State 2 | Box score |
| Apr 15, 2022 | Detroit, Mich. | Grand Valley State 8, Wayne State 6 | Box score |
| Apr 15, 2022 | Detroit, Mich. | Wayne State 4, Grand Valley State 1 | Box score |
| Apr 14, 2022 | Detroit, Mich. | Wayne State 10, Grand Valley State 8 | Box score |
| Apr 10, 2022 | Detroit, Mich. | Wayne State 11, Saginaw Valley 3 | Box score |
| Apr 10, 2022 | Detroit, Mich. | Wayne State 7, Saginaw Valley 4 | Box score |
| Apr 9, 2022 | Detroit, Mich | Wayne State 6, Saginaw Valley 5 | Box score |
| Apr 8, 2022 | Detroit, Mich. | Wayne State 10, Saginaw Valley 8 | Box score |
| Apr 5, 2022 | Detroit, Mich. | Wayne State 10, Parkside 2 | Box score |
| Apr 5, 2022 | Detroit, Mich. | Wayne State 12, Parkside 0 | Box score |
| Apr 3, 2022 | Caledonia, Mich. | Wayne State 6, Davenport 1 | Box score |
| Apr 3, 2022 | Caledonia, Mich. | Davenport 5, Wayne State 4 | Box score |
| Apr 2, 2022 | Caledonia, Mich. | Wayne State 3, Davenport 2 | Box score |
| Apr 1, 2022 | Caledonia, Mich. | Davenport 3, Wayne State 1 | Box score |
| Mar 30, 2022 | Hillsdale, Mich. | Hillsdale 10, Wayne State 9 | Box score |
| Mar 22, 2022 | Findlay, Ohio | Wayne State 7, Findlay 3 | Box score |
| Mar 19, 2022 | Davenport, Fla. | Wayne State 7, Southwest Baptist 4 | Box score |
| Mar 19, 2022 | Davenport, Fla. | Wayne State 5, Southwest Baptist 1 | Box score |
| Mar 17, 2022 | Winter Haven, Fla. | Wayne State 14, Southwest Baptist 1 | Box score |
| Mar 15, 2022 | Auburndale, Fla. | Grand Valley State 7, Wayne State 4 | Box score |
| Mar 13, 2022 | Auburndale, Fla. | Wayne State 3, Ashland 0 | Box score |
| Mar 12, 2022 | Davenport, Fla. | Sioux Falls 4, Wayne State 1 | Box score |
| Mar 12, 2022 | Davenport, Fla | Wayne State 9, Sioux Falls 2 | Box score |
| Mar 11, 2022 | Lakeland, Fla. | Wayne State 11, Augustana (S.D.) 10 | Box score |
| Mar 11, 2022 | Lakeland, Fla. | Augustana (S.D.) 4, Wayne State 2 | Box score |
| Mar 6, 2022 | Indianapolis, Ind. | Wayne State 13, Indianapolis 3 | Box score |
| Mar 5, 2022 | Indianapolis, Ind. | Wayne State 26, Indianapolis 11 | Box score |
| Mar 5, 2022 | Indianapolis, Ind. | Wayne State 13, Indianapolis 2 | Box score |
| Mar 4, 2022 | Indianapolis, Ind. | Indianapolis 5, Wayne State 3 | Box score |
| Feb 20, 2022 | Hendersonville, Tenn | Wayne State 7, Tiffin 2 | Box score |
| Feb 20, 2022 | Hendersonville, Tenn | Tiffin 5, Wayne State 2 | Box score |
| Feb 19, 2022 | Hendersonville, Tenn | Wayne State 9, Tiffin 0 | Box score |
| Feb 18, 2022 | Hendersonville, Tenn | Wayne State 5, Tiffin 3 | Box score |