| Date | Location | Result | |
| 03/11/22 | Ashland, OH | Grand Valley St. 72, Wayne State 46 | Box score |
| 03/05/22 | Allendale, MI | Ferris St. 62, Wayne State 60 | Box score |
| 03/02/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 70, Wis.-Parkside 65 | Box score |
| 02/26/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 74, Davenport 35 | Box score |
| 02/24/22 | Detroit, MI (Wayne State Fieldhouse) | Grand Valley St. 63, Wayne State 54 | Box score |
| 02/19/22 | Houghton, MI | Michigan Tech 72, Wayne State 69 (OT) | Box score |
| 02/17/22 | Marquette, MI | Wayne State 61, Northern Mich. 37 | Box score |
| 02/15/22 | Sault Ste. Marie, MI | Wayne State 80, Lake Superior St. 44 | Box score |
| 02/12/22 | Detroit, MI (Wayne State Fieldhouse) | Wis.-Parkside 64, Wayne State 55 | Box score |
| 02/10/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 59, Purdue Northwest 47 | Box score |
| 02/07/22 | Midland, MI (Riepma Arena) | Wayne State 81, Northwood 65 | Box score |
| 02/03/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 70, Saginaw Valley 62 (OT) | Box score |
| 01/29/22 | Detroit, MI (Wayne State Fieldhouse) | Ferris St. 73, Wayne State 65 | Box score |
| 01/27/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 75, Lake Superior St. 50 | Box score |
| 01/22/22 | Hammond, IN | Wayne State 60, Purdue Northwest 48 | Box score |
| 01/20/22 | Kenosha, WI | Wayne State 85, Wis.-Parkside 84 | Box score |
| 01/15/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 71, Northern Mich. 56 | Box score |
| 01/13/22 | Detroit, MI (Wayne State Fieldhouse) | Michigan Tech 66, Wayne State 60 | Box score |
| 01/06/22 | Big Rapids, MI | Wayne State 60, Ferris State 45 | Box score |
| 01/02/22 | University Center, MI | Saginaw Valley 69, Wayne State 67 | Box score |
| 12/11/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 62, Northwood 59 | Box score |
| 12/04/21 | Allendale, MI | Grand Valley St. 72, Wayne State 35 | Box score |
| 12/02/21 | Grand Rapids, MI (DU Student Center) | Wayne State 58, Davenport 50 | Box score |
| 11/28/21 | Ashland, OH | Ashland 71, Wayne State 59 | Box score |
| 11/24/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 102, Central St. (OH) 51 | Box score |
| 11/17/21 | Cedarville, OH | Wayne State 85, Cedarville 83 (OT) | Box score |
| 11/14/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 82, Walsh 64 | Box score |
| 11/13/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 75, Lake Erie 45 | Box score |