| Date | Location | Result | |
| 02/26/22 | Detroit, MI (Wayne State Fieldhouse) | Davenport 90, Wayne State 64 | Box score |
| 02/24/22 | Detroit, MI (Wayne State Fieldhouse) | Grand Valley St. 62, Wayne State 53 | Box score |
| 02/19/22 | Houghton, MI | Michigan Tech 82, Wayne State 57 | Box score |
| 02/17/22 | Marquette, MI | Northern Mich. 65, Wayne State 53 | Box score |
| 02/12/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 72, Wis.-Parkside 67 | Box score |
| 02/10/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 56, Purdue Northwest 53 | Box score |
| 02/07/22 | Midland, MI (Riepma Arena) | Northwood 80, Wayne State 77 | Box score |
| 02/03/22 | University Center, MI | Saginaw Valley 67, Wayne State 65 | Box score |
| 01/29/22 | Detroit, MI (Wayne State Fieldhouse) | Ferris St. 75, Wayne State 60 | Box score |
| 01/27/22 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 68, Lake Superior St. 60 | Box score |
| 01/22/22 | Hammond, IN | Purdue Northwest 93, Wayne State 75 | Box score |
| 01/20/22 | Kenosha, WI | Wis.-Parkside 89, Wayne State 69 | Box score |
| 01/15/22 | Detroit, MI (Wayne State Fieldhouse) | Northern Mich. 88, Wayne State 78 | Box score |
| 01/13/22 | Detroit, MI (Wayne State Fieldhouse) | Michigan Tech 62, Wayne State 51 | Box score |
| 01/10/22 | Big Rapids, MI | Ferris State 104, Wayne State 73 | Box score |
| 01/08/22 | Sault Ste. Marie, MI | Lake Superior St. 73, Wayne State 63 | Box score |
| 12/18/21 | Detroit, MI (Wayne State Fieldhouse) | Saginaw Valley 67, Wayne State 55 | Box score |
| 12/11/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 65, Northwood 57 | Box score |
| 12/04/21 | Allendale, MI | Grand Valley St. 70, Wayne State 63 | Box score |
| 12/02/21 | Grand Rapids, MI | Davenport 71, Wayne State 59 | Box score |
| 11/20/21 | Detroit, MI (Wayne State Fieldhouse) | Hillsdale 68, Wayne State 62 | Box score |
| 11/17/21 | Detroit, MI (Wayne State Fieldhouse) | Wayne State 68, Lewis 66 | Box score |
| 11/12/21 | Ashland, OH (Kates Gymnasium) | Ashland 59, Wayne State 50 | Box score |