| Date | Location | Result | |
| 03/04/21 | Westville, Ind. | Saginaw Valley 69, Wayne State 58 | Box score |
| 03/02/21 | Detroit, Mich. (Matthaei) | Wayne State 81, Lake Superior St. 63 | Box score |
| 02/27/21 | Big Rapids, Mich. | Wayne State 59, Ferris State 54 | Box score |
| 02/26/21 | Big Rapids, Mich. | Wayne State 48, Ferris State 47 | Box score |
| 02/20/21 | University Center, Mich. | Wayne State 79, Saginaw Valley 70 (OT) | Box score |
| 02/19/21 | University Center, Mich. | Saginaw Valley 78, Wayne State 63 | Box score |
| 02/16/21 | Detroit, Mich. (Matthaei) | Wayne State 65, Ashland 64 | Box score |
| 02/13/21 | Detroit, Mich. (Matthaei) | Wayne State 82, Wis.-Parkside 77 (OT) | Box score |
| 02/12/21 | Detroit, Mich. (Matthaei) | Wayne State 69, Wis.-Parkside 60 | Box score |
| 02/06/21 | Hammond, Ind. | Purdue Northwest 81, Wayne State 64 | Box score |
| 02/05/21 | Hammond, Ind. | Wayne State 61, Purdue Northwest 56 (OT) | Box score |
| 01/31/21 | Detroit, Mich. (Matthaei) | Grand Valley St. 61, Wayne State 49 | Box score |
| 01/30/21 | Detroit, Mich. (Matthaei) | Grand Valley St. 66, Wayne State 57 | Box score |
| 01/26/21 | Ashland, Ohio - Kates Gymnasium | Ashland 83, Wayne State 68 | Box score |
| 01/23/21 | Detroit, Mich. (Matthaei) | Northwood 78, Wayne State 63 | Box score |
| 01/22/21 | Detroit, Mich. (Matthaei) | Wayne State 77, Northwood 69 | Box score |
| 01/16/21 | Grand Rapids, Mich. (DU Student Center) | Davenport 60, Wayne State 58 | Box score |
| 01/15/21 | Grand Rapids, Mich. (DU Student Center) | Wayne State 91, Davenport 57 | Box score |
| 01/12/21 | Detroit, Mich. (Matthaei) | Wayne State 79, Lake Superior St. 61 | Box score |
| 01/11/21 | Detroit, Mich. (Matthaei) | Wayne State 75, Lake Superior St. 52 | Box score |